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Tripathi, D. K.

• Multidose Therapy (MDT) Treatment for Helicobacter Pylori Infection Leading to Gastric Ulcer and Carcinoma: A Review

Abstract Views :227  |  PDF Views:2

Authors

Amit Alexander ¹, D. K. Tripathi ², Ajazuddin ², Mukesh Singh ², Monesh Sahu ², Swarna ²

Affiliations
1 Department of Pharmaceutics Rungta College of Pharmaceutical Sciences and Research, Bhilai, IN
2 Rungta College of Pharmaceutical Sciences and Research, Bhilai, IN

Source

Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 3 (2011), Pagination: 140-147

Abstract

The realization that Helicobacter pylori is one of the most important etiological factors for peptic ulcer has had an enormous impact on approach to the management of ulcer disease leading to gastritis, gastric cancer and duodenal ulcer which has been a major problem in India as well as western and southern country. Helicobacter pylori is one of the microorganism which can easily survive in highly acidic medium in gastrointestinal tract even though they can survive in acid of car battery; so, there are various treatment schedules just like single, double and triple drug therapy including antibiotics, proton pump inhibitors, antacids, antiamoebic and H₂ blockers. These drugs are used in the combination therapy for a specific period of time and high eradication rate 86-90% of Helicobacter pylori is observed in case of triple drug therapy, for the best result triple drug therapy (proton pump inhibitors, antibiotics & H₂ blockers) along with antacids must be employed in the treatment of Helicobacter pylori infection leading to gastric ulcer and gastric carcinoma because triple drug therapy reduces total duration of therapy.

Keywords

H. pylori, Gastritis, Duodenal Ulcer, Gastric Carcinoma.

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References

• Mehmood Arshad, Akram M., Shahab-uddin, Ahmed Afzal, Khan Usmanghani, Hannan Abdul, Mohiuddin E., Asif M. Helicobacter pylori: an introduction. IJABPT. Volume: I: Issue-3: Nov-Dec -2010. ISSN 0976-4550.
• Parsonnet Julie, Friedman D. Gary, Vandersteen P. Daniel, Chang Yuan, Vogelman H. Joseph, Orentreich Norman, and Sibley K. Richard. Helicobacter pylori Infection and the Risk of Gastric Carcinoma. The New England Journal of Medicine. 1991; 325:1127-1131october 17, 1991.
• Yvonne T.H.P. van Duynhoven1 & Rob de Jonge. Transmission of helicobacter pylori : a role for food. Bulletin of the World Health Organization. 2001, 79: 455–460.
• Watanabe Takeshi , Tada Mayumi , Nagai Hirofumi , Sasaki Satoshi , Nakao Masafumi. Helicobacter pylori infection induces gastric cancer in Mongolian gerbils. Official Journal of AGA Institute. Volume 115, Issue 3 , Pages 642-648, September 1998.
• Kawamura Masashi, Abe Shu, Oikawa Keisuke, Terai Shiho, Saito Masahiro, Shibuya Daisuke, Kato Katsuaki, Inomata Yoshifumi, Ohara Shuichi, Shimosegawa Tooru. Digestive Endoscopy. Digestive Endoscopy © 2010 Japan Gastroenterological Endoscopy Society. Volume 23, Issue 1, pages 37–42, January 2011.
• Malaty M. Hoda. Epidemiology of Helicobacter pylori infection. Best Practice & Research Clinical Gastroenterology. Vol. 21, No. 2, pp. 205-214, 2007. Available from: URL: <http://www.sciencedirect.com>
• Perez-Perez I. Guillermo, Rothenbacher Dietrich and Brenner Hermann. Epidemiology of Helicobacter pylori Infection. Volume 9, Supplement 1, 2004.
• BSCI 424 pathogenic microbiology fall 2000.university of maryland. Available from URL:<http://www.life.umd.edu/classroom/bsci424/PathogenDescriptions/Helicobacter.htm>
• Olbe Lars, Fandriks Lars, Hamlet Annika, Svennerholm Ann-Mari and Thoreson Ann-Catrin. Mechanisms involved in Helicobacter pylori induced duodenal ulcer disease. World Journal of Gastroenterology. 2000; 6(5):619-623, ISSN 1007-9327.
• Andersen AP, Elliott DA, Lawson M, Barland P, Hatcher VB and Puszkin EG. Growth and morphological transformations of Helicobacter pylori in broth media [In Process Citation]. Journal of Clinical Microbiology, Nov 1997, 2918-2922, Vol 35, No. 11.
• Bode G., Mauch F. And Malfertheiner P. The coccoid forms of Helicobacter pylori. Criteria for their viability. Epidemiol. Infect. (1993), 111, 483-490.
• Grubel P, Hoffman JS, Chong FK, Burstein NA, Mepani C and Cave DR. Vector potential of houseflies (Musca domestica) for Helicobacter pylori. Journal of Clinical Microbiology, 06 1997, 1300-1303, Vol 35, No. 6.
• Dunn BE, Cohen H and Blaser MJ. Helicobacter pylori. Clinical Microbiology Reviews, Oct 1997, 720-741, Vol 10, No. 4.
• Tsang KW, Lam SK. Extragastroduodenal conditions associated with Helicobacter pylori infection. Hongkong Medical Journal. June 1999; 5:169-174 Vol. 5 No 2.
• Salmela K. S., Roine R. P. , Hook-Nikanne J. , Kosunen T. U. and Salaspuro M. Acetaldehyde and Ethanol Production by Helicobacter pylori. Scandinavian Journal of Gastroenterology. 1994, Pages 309-312, Vol. 29, No. 4.
• Konturek S.J., Konturek P.C., Konturek J.W., Plonka M., Czesnikiewicz-Guzik M., Brzozowski T., Bielanski W. Helicobacter pylori and its involvement in gastritis and peptic ulcer formation. Available from: URL:< http://www.jpp.krakow.pl/journal/archive/09_06_s3/articles/03_article.html>
• Beswick J Ellen, Suarez Giovanni, Reyes E Victor. H pylori and host interactions that influence pathogenesis. World Journal of Gastroenterology. 2006 September 21; 12(35): 5599-5605. ISSN 1007-9327. Available from URL: <http://www.wjgnet.com/1007-9327/12/5599.asp>
• Kusters G. Johannes, Vliet H. M. van Arnoud, and Kuipers J. Ernst. Pathogenesis of Helicobacter pylori Infection. Clinical Microbiology reviews, july 2006, p. 449–490, Vol. 19, No. 3.
• EL-Zimaity HM., Recent advances in the histopathology of gastritis.Current Diagnostic pathology, 13, 2007, 340-348
• Dixon MF., Genta RM., Yardley J., Classification and grading of gastritis. Am J Surg Pathol, 20, 1996, 1161-1181.
• Elseweidy M. Mohamed ,Taha M. Mona , Younis Nahla N. Younis, Ibrahim S. Khadiga , Hamouda A. Hamdi , Eldosouky A. Mohamed, soliman Hala , Ghate Samir. Pattern of gastritis as manipulated by current state of Helicobacter pylori infection. International Journal of Biology and Biomedical Engineering. Issue 1, Volume 4, 2010.
• Dixon MF. Helicobacter pylori and peptic ulceration: histopathological aspects. J Gastroenterol Hepatol 1991;6:125–30.
• Moayyedi Paul, Wason Catriona, Peacock Robert, Walan Anders, Bardhan Karna, Axon T. R. Anthony, and Dixon F. Michael. Changing Patterns of Helicobacter pylori Gastritis inLong-Standing Acid Suppression. Blackwell Science page no.206-214, Volume 5 Number 4 2000.
• Kato Ikuko , Nomura M. Y. Abraham , Stemmermann N. Grant , Chyou Po-Huang . A Prospective Study of Gastric and Duodenal Ulcer and Its Relation to Smoking, Alcohol, and Diet. American Journal of Epidemiology 1992, 135 (5): 521-530.
• Hompes A David. H pylori symptoms. Available from URL: <http://hpylori-symptoms.com/h-pylori-symptoms/>
• Gold D. Benjamin, Colletti B. Richard, Abbott Myles, Czinn J. Steven, Elitsur Yoram, Hassall Eric, Macarthur Colin, Snyder John, and Sherman M. Philip. Helicobacter pylori Infection in Children: Recommendations for Diagnosis and Treatment. Journal of Pediatric Gastroenterology and Nutrition, November 2000:490–497, Vol. 31, No. 5.
• Hardin J. Frederick, Wright A. Richard. Helicobacter pylori: Review and Update. Hospital Physician May 2002.Available from URL: <www.turner-white.com>
• Jiang Zheng, Huang Ai-Long, Tao Xiao-Hong, Wang Pi-Long. Diagnosis of Helicobacter pylori infection and diseases associated with Helicobacter pylori by Helicobacter pylori outer membrane proteins. World Journal of Gastroenterology 2004; 10(23):3464-3469, ISSN 1007-9327.
• Trautmann Karolin, Stolte Manfred, Miehlke Stephan. Eradication of H pylori for the prevention of gastric cancer. World Journal of Gastroenterology 2006 August 28; 12(32): 5101-5107, ISSN 1007-9327.
• Donovan J. Arthur, Berne V. Thomas, Donovan A. John. Perforated Duodenal Ulcer: An Alternative Therapeutic Plan. Archives of surgery VOL 133, NOV 1998. Available from URL:<http://archsurg.amaassn.org/cgi/content/full/133/11/1166>
• Aguilar R. German, Ayala Guadalupe, Fierros-Zarate Geny. Helicobacter pylori: Recent advances in the study of its pathogenicity and prevention.SciELO Public Health vol.43, no.3, may-june 2001.
• Kate Vikram , Ananthakrishnan N . Treatment of helicobacter pylori infection: A review. Indian journal of pharmacology 2001; 33: 410-416.
• Gerrits M Monique, Vliet HM van Arnoud, Kuipers J Ernst, Kusters G Johannes. Helicobacter pylori and antimicrobial resistance: molecular mechanisms and clinical implications. The Lancet Infectious Diseases. Volume 6, Issue 11, November 2006, Pages 699-709.
• Stenstrom Bjorn Mendis Aruni, Marshall Barry. Helicobacter pylori: the latest in diagnosis and treatment. Reprinted from Australian Family Physician Vol. 37, No. 8, August 2008.

• Effect of Different Fertility Level and Micronutrients on Nodulation and Nutrient Uptake by Chickpea

Abstract Views :197  |  PDF Views:0

Authors

Suresh Kumar ¹, D. K. Tripathi ¹, Ram Bharose ¹, Maneesh Kumar ¹, Ravendra Kumar ¹

Affiliations
1 Department of Soil Science and Agricultural Chemistry, College of Agriculture, N.D. University of Agriculture and Technology, Kumarganj, Faizabad (U.P.), IN

Source

An Asian Journal of Soil Science, Vol 11, No 1 (2016), Pagination: 62-66

Abstract

The field experiment was conducted during Rabi season 2013-14 to evaluate the effect of different fertility level and micronutrients on nodulation and nutrient uptake of chickpea (Cicer arietinum L.) to fertility levels and micronutrients. Twelve treatments combinations was comprised with three fertility levels -F_1:40 kg P₂O₅ha^-1, F_2:60 kg P₂O₅ + 20 kg S ha^-1and F_3:80 kg P₂O₅ + 40 kg S ha^-1 and four micronutrient levels- M_0: control, M_1:3 kg Zn ha^-1, M_2:0.3 per cent B spray ha^-1 and M_3:3 kg Zn + 0.3 per cent B spray ha^-1 were laid out in Spilt Plot Design. The maximum growth, yield, nodulation and nutrient uptake were recorded with higher level of fertility application F_3: 80 kg P₂O₅ and 40 kg which was significantly superior over lower level of fertility F₁ and statistically at par with F_2. The minimum response was recorded with the application of lower fertility level F₁ with micronutrient application.

Keywords

Chickpea, Fertility Level,Micronutrients, Nodulation, Nutrient Uptake.

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References

• Ahalwat, I.P.S., Gangaiah, B. and Zadid, A.M. (2007). Nutrient management in chickpea. In: Chickpea breeding and management (Yadav, S.S.; Redden, R.; Chen, W. and Sharma, B. eds.) CAB International, Wallingford, Oxon, United Kingdom, 213-232pp.
• Ali, M.Y., Krishnamurthy, L., Saxena, N.P., Rupela, O.P., Kumar, J. and Johansen, C. (2002). Scope for genetic manipulation of mineral acquisitions in chickpea. Plant Soil, 24 (5): 123-134.
• Anonymous (2013). Annual report (Rabi, 2012-13) All India Co-ordinated Research Project (ICAR).
• Chesnin, L. and Yien, C.H. (1951).Turbidimetric determination of available sulphate. Soil Sci. Soc. America Proc., 14 : 149-151
• Chopra, S.L. and Kanwar, J. S. (1991).Analytical agricultural chemistry, Kalyani Publishers, NEW DELHI, INDIA.
• Jeckson, M.L. (1973). Soil chemical analysis. Prentice hall of India Pvt. Ltd, NEW DELHI, INDIA.
• Kharol, S., Sharma, M., Lal, M. and Sumeriya, H.K. (2014). Productivity of chickpea (Cicer arietinum L.) as influenced by sulphur and zinc under agroclimatic zone IV-A of Rajsthsn. Ann. Biol., 30 (4): 676-680
• Lal, B., Rana, K.S., Rana, D.S., Gautam, P., Shivay, Y.S., Ansari, M.A., Meena, B.P. and Kumar, K. (2014). Influence of intercropping, moisture conservation practice and P and S levels on growth, nodulation and yield of chickpea (Cicer arietinum L.) under rainfed condition. Leg. Res., 37 (3): 300-305.
• Lindsay, M.L. and Norvell, W.A. (1978). Development of DTPA test for Zn. J. American Soc. Soil Sci., 42: 421-428.
• Mishra, S.K., Upadhyay, R.M. and Tiwari, V.N. (2002). Effect of salt and zinc on nodulation leghaemoglobin and nitrogen content of Rabi legume. Indian J. Pulse Res., 15 (2): 145-148.
• Neenu, S., Ramesh, K., Ramana, S., Biswas, A.K. and Rao, A.S. (2014). Growth and yield of different varieties of chickpea (Cicer arietinum L.) as influenced by the phosphorus nutrition under rainfed conditions on vertisols. Internat. J. Bio-resour. & Stress Mgmt., 5 (1): 53-57.
• Olsen, S.R., Cole, C.V., Watanable, F.S. and Dean, L.A. (1956). Estimation of available phosphorus in soil by extraction with sodium bicarbonate. USDA, Cric 930: 19-23 (C.F. methods of soil analysis. Ed. Black: C.A. Agronomy, No. 9 Am. Soc. Agron. Inc. Madison, Wisconsin, 1044-1046pp.
• Patel, H.K., Patel, P.M. and Patel, M.R. (2013). Effect of sulphur and phosphorus management on growth and yield of chickpea. Adv. Res. J. Crop Improv., 4 (2): 103-105
• Rao, R.N., Finck, A., Blair, G.J. and Tondan, H.L.S. (2006). Plant nutrition for food security. A guide for integrated nutrient management. Fertilizer and plant nutrition Bulletin 16. Food and Agriculture Organization of the United Nations, Rome Italy, 368.
• Sasode, N.K. and Patil, D.S.A. (2003). Yield, nutrient uptake and economics of gram (Cicer arietinum L.) as influenced by P and S levels and PSB inoculation under irrigated conditions. Leg. Res., 23 (2): 125-127.
• Sharma, A.K., Raghubanshi, P.B.S. and Siorothia, P. (2014). Response of chickpea to levels of zinc and phosphorus. Ann. Plant & Soil Res., 16 (2): 172.173 .
• Sharma, S.K. and Jain, N.K. (2012). Effect of balanced fertilization on productivity and soil fertility status of clusterbean. Leg. Res., 35 (1): 32-35.
• Singh, Y., Singh, B. and Kumar, D. (2014). Effect of phosphorus levels and biofertilizers on yields attributes, yield and nutrient uptake of chickpea (Cicer arietinum L.) under rainfed condition. Res. Crops, 15 (1): 90-95.
• Subbiah, B.V. and Asija, C.L. (1956). A rapid procedure for the estimation of available N in soil. Curr. Sci., 25: 259-260.
• Walkley, A. and Black, A.I. (1934). Old piper, S.S. Soil and plant analysis, Nans Publishers Bombay, Soil Sci., 37 29-38.

• Natural Humectants in formulation of Calamine Lotion:Its Evaluation and Comparison

Abstract Views :518  |  PDF Views:0

Authors

Harsha Solanki ¹, Vinay Sagar Verma ¹, Mukesh Sharma ¹, Ajay Singh ², Garima Sharma ¹, Manisha Majumdar ¹, Sujata Gupta ¹, Sandhya ¹, Vandana Sahu ¹, Kalyani Dewangan ¹, D. K. Tripathi ¹, Amit Alexander ¹, Ajazuddin ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kurud Road Kohka, Bhilai, Chhattisgarh, 490024, IN
2 GD Rungta College of Science and Technology, Kurud Road Kohka, Bhilai, Chhattisgarh, 490024, IN

Source

Research Journal of Topical and Cosmetic Sciences, Vol 7, No 2 (2016), Pagination: 41-45

Abstract

Herbal cosmetics are formulated, using different cosmetic ingredients to form the base in which one or more herbal ingredients are used to cure various skin ailments. The name itself suggests that herbal cosmetics are natural and free from all the harmful synthetic chemicals which otherwise may prove to be toxic to the skin. Compared to other beauty products, natural cosmetics are safe to use. Cosmeceuticals are cosmetic-pharmaceutical hybrid products intended to improve the health and beauty of the skin by providing a specific result, ranging from acne-control and anti-wrinkle effects, to sun protection. Calamine lotion is widely used as an antiseptic and protective for its cooling and soothing effect in various skin disorders. Instead of traditional synthetic products different plant parts and plant extracts are used in this study to procure calamine lotion having natural humectants, e.g. aloe-vera gel and honey. Herbal cosmetics are the preparations used to enhance the human appearance. The purpose of this study is to compare the semi synthetic activity of glycerin with other humectants in terms of their emollient properties to ensure whether calamine lotion can be formulated using natural humectants or not.

Keywords

Humectants, Emollient, Antiseptic, Calamine Lotion.

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• A Survey on Marketed Products Having Significance Role in Hair Loss Treatment:Bhilai-Durg City 2011-12

Abstract Views :314  |  PDF Views:0

Authors

Sharma Mukesh ¹, Ajazuddin ¹, V. Minu ¹, Soni Sonam ¹, Jyotsna ¹, Rashmi ¹, Hansa ², Deepaveni ¹, Hempushpa ¹, D. K. Tripathi ¹

Affiliations
1 Rungta Collage of Pharmaceutical Science and Research, Kurud, Bhilai-490026 (C.G.), IN
2 Rungta Collage of Pharmaceutical Science Bhilaiand Research, Kurud, Bhilai-490026 (C.G.), IN

Source

Research Journal of Topical and Cosmetic Sciences, Vol 3, No 2 (2012), Pagination: 37-39

Abstract

Hair is a fashion statement, its style&adornment can express person mood , outlook&attitude and when it is loss we lose our confidence .The average person has five million hairs (100,000 - 150,000 are on the scalp) hair is composed of keratin hair are produced by a small structure underneath the skin called the hair follicles. The aim of the current study was to explore the available brand in the market that is used in the treatment of hair loss. Data were collected by mailed questionnaires in 2012 March-April from a Local sample of Bhilai-Durg city, State-Chhattisgarh having group of medical stores (33), general stores (41) and fancy stores (26). It has been found that out of 22 brands sesa oil, keshking oil, Parachute oils, are the most available brands in market. It has been also found that shampoos like Head&Shoulder Shampoo, Sesa Shampoo, Clinic plus Shampoo, and Sunsilk Shampoo are most available in market for the treatment of hair loss. Also found that Aloevera, Amla, Bahera, Bhringraj Brahmi, Harra, Mehndi, Neem, OliveOil, Shikakai, yastiMadhu are the most useful herbal drugs in the hair oil preparation.

Keywords

Hair Loss Treatment, Bhringraj, Shampoo, Hair Oil, Brahmi, Shikakai.

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• A Study on Natural Plants Having Insect Repellent Activity

Abstract Views :148  |  PDF Views:0

Authors

Soyeb Khan ¹, Mukesh Sharma ¹, Ajazuddin ¹, Amit Alexander ¹, Junaid Khan ¹, Khushboo Dubey ¹, Shruti Mohanty ¹, D. K. Tripathi ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, IN

Source

Research Journal of Pharmacognosy and Phytochemistry, Vol 4, No 2 (2012), Pagination: 130-133

Abstract

Plant-based repellents have been used for generations in traditional practice as a personal protection measure against host-seeking insect. Recently, commercial repellent products containing plant-based ingredients have gained increasing popularity among consumers, as these are commonly perceived as "safe" in comparison to long-established synthetic repellents. There is a need for further standardized studies in order to better evaluate repellent compounds and develop new products that offer high repellency as well as good consumer safety. How often have we tried to enjoy the great outdoors or a restful night sleep only to be bothered by what seems like an army of insects attacking us? What is it that attracts insects to humans? Are some individuals more attractive to insects than other individuals? Since insects are vectors for many debilitating human diseases, understanding insect attraction to humans is very important. Study has shown that insects associate with humans at multiple stages in their life cycle. The mechanism of this attraction, i.e. CO2, sweat, ABO blood type, chemicals, body temperature, body humidity. For example, scabies mite, Sarcoptes scabies, which can cause intense skin irritation, has been found to be attracted by host odor, body temperature. CO2 plays a significant role in attraction for numerous insects especially mosquitoes. Other examples of insect attraction to humans include: kissing bugs and sandflies. Study has also shown that the common natural plant like Fennel, Neem, Basil, Coriander are having excellent insect repellent activity with medicinal significance.

Keywords

Insect Repellent Plant, Mosquitoes, Kissing Bugs, Sand Flies.

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• Study of the Medicinal Significance of Weeds-A Review

Abstract Views :146  |  PDF Views:0

Authors

Khushboo Dubey ¹, Mukesh Sharma ¹, Shruti Mohanty ¹, Ajazuddin ¹, Amit Alexander ¹, Junaid Khan ¹, Khumesh Verma ¹, D. K. Tripathi ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, IN

Source

Research Journal of Pharmacognosy and Phytochemistry, Vol 4, No 1 (2012), Pagination: 53-58

Abstract

Weeds are unwanted and undesirable plants which interfere with the utilization of land and water resources and thus adversely affect human welfare. They can also be referred to as plants out of place. In crop lands and forests, weeds compete with beneficial and desired vegetation, reducing the yield and quality of produce. But it is also true that while all unwanted plant are weeds, all weeds are not unwanted plants.. Weeds are not unwanted plants for practitioners of Ayurvedic and other traditional systems of healing. For them, weeds are potenital sources of valuable life-saving drugs. In additional, allelopathic and industrial uses of common weeds have been reported. With the help of information available in ancient and modern literature, farmers can utilize these so-called unwanted plants (i.e. weeds) to generate additional income. The present paper is a review article on the weeds of Chhatisgarh and India. Here medicinal significance of 20 weeds of Chhattisgarh and 10 weeds found in other parts of Chhattisgarh has been discussed. These weeds like Boerhavia diffusa, Achyranthus aspera having the medicinal significance can be used for the treatment of many diseases, and also can act as source of income for farmers.

Keywords

Weeds, Medicinal Significance.

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• A Review on Pharmacological Profile for Phytomedicine Known as Linn

Abstract Views :202  |  PDF Views:0

Authors

Hemant Badwaik ¹, Tapan Kumar Giri ¹, D. K. Tripathi ¹, Mukesh Singh ¹, Abdul Hanif Khan ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Bhilai (C.G), IN

Source

Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 3 (2011), Pagination: 103-107

Abstract

Application indigenous natural products has been alternative way to replace synthetic medicine Gloriosa superba is a well known ethnomedicinal plant which is used in Ayurveda. Photochemical studies of G. superba shows presence of colchicin, b-siltosterol, long chain fatty acids, b and glumiccolchicines, 2-hydroxy-6-methoxy benzoic, luterlin, N-formyl-deacetyl colchicines and new colchicine glycoside, 3-O-demethylcolchicine-3-Oalpha- D- glucopyranoside. FDA-approved use of Colchicine is to treat gout (it is one of the active ingredients of anti-gout tablets marketed by Merck&amp;Co.). It is also used as an anticancer, antimicrobial, antifungal, anticoagulant, antilipoxygenase agent and antidote in snake bite. However, ingestion of all parts of the plant is extremely poisonous and can be fatal. The commonest clinical presentation of poisoning is severe gastroenteritis with nausea, vomiting, diarrhoea with b leading to dehydration, hypovolaemic shock and acute renal failure. Gloriosa superba usually multiply by corm and seeds but due to low germination capability it restricts for the regeneration. Therefore, in order to safeguard and preserve this important plant biotechnological approachs would be very useful. Micropropagation of Gloriosa superba meets ever increasing demands for colchicine. The availability from both wild and cultivated sources make the plant of Gloriosa superba a potential source of Colchicine in India.

Keywords

Gloriosa superba Linn., 3-O-Demethylcolchicine-3-Oalpha- D- Glucopyranoside, Antitumor, Gout, Gastroenteritis.

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• Ignition Delay Study of Aluminium Oxide Liquid Nano-Fuel in a Shock Tube

Abstract Views :199  |  PDF Views:74

Authors

D. K. Tripathi ¹, G. Garg ², U. Agrawal ², V. Menezes ¹, U. V. Bhandarkar ², B. P. Puranik ²

Affiliations
1 Department of Aerospace Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, IN
2 Department of Mechanical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, IN

Source

Current Science, Vol 112, No 07 (2017), Pagination: 1561-1564

Abstract

The ignition delay of aluminium oxide (Al₂O₃) liquid nano-fuel was compared with that of base-fuel to study the feasibility of its use for high-speed aerospace applications. The base-fuel was aviation turbine fuel that was mixed with Al₂O₃ nanoparticles to produce a nano-fuel which could be used for regenerative cooling of the combustor walls before injection. The experiments were carried out in a shock tube. The fuel was introduced into the shock tube in the form of a wall droplet. The ignition delay time of the nano-fuel was observed to increase slightly, by about 11% (maximum) in comparison with the baseline, at an equivalence ratio of unity.

Keywords

Aluminium Oxide, Ignition Delay, Liquid Nano-Fuel, Shock Tube.

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References

• Nagaboopathy, M., Vijayanand, C., Hegde, G., Reddy, K. P. J. and Arunan, E., Single-pulse chemical shock tube for ignition delay measurements. Curr. Sci., 2008, 95(1), 78–82.
• Sonawane, S., Bhandarkar, U., Puranik, B. and Kumar, S. S., Convective heat transfer characterization of aviation turbine fuel–metal oxide nano-fluids. J. Thermophys. Heat Transfer, 2012, 26(4), 619–628.
• Milton, B. E., Atomization of liquid droplets on surfaces exposed to moving shock waves. Shock Waves, 2006, 16(2), 95–107.
• Anderson Jr, J. D., In Modern Compressible Flow: With Historical Perspective (eds Beamesderfer, L. and Morriss, J. M.), McGrawHill, Singapore, 1990, 2nd edn, pp. 209–212.
• Gauthier, B. M., Davidson, D. F. and Hanson, R. K., Shock tube determination of ignition delay times in full-blend and surrogate fuel mixtures. Combus. Flame, 2004, 139(4), 300–311.
• Vandersickel, A. et al., The autoignition of practical fuels at HCCI conditions: high-pressure shock tube experiments and phenomenological modeling. Fuel, 2012, 93, 492–501.
• Litke, P. J., Schauer, F. R., Paxson, D. E., Bradley, R. P. and Hoke, J. L., Assessment of the performance of a pulsejet and comparison with a pulsed-detonation engine. AIAA paper No. 2005-0228.
• Ma, F., Choi, J. Y. and Yang, V., Thrust chamber dynamics and propulsive performance of single-tube pulse detonation engines. J. Propulsion Power, 2005, 21(3), 512–526.
• Bussing, T. R. A., Bratkovich, T. E. and Hinkey, J. B., Practical implementation of pulse detonations engines. AIAA paper No. 1997-2748.

• Underlining some Important Aspects behind the Role of Enzyme Immobilization in Pharmaceutical Technology

Abstract Views :148  |  PDF Views:1

Authors

Simran Kukreja ¹, Sonal Priya ¹, Shraddha Bhondekar ¹, Nupur Verma ¹, Sonal Jain ¹, Aivant Golchha ¹, Ganesh Sinha ¹, Shubham Kumar ¹, Chandan Mandal ¹, Asha Patel ¹, Mukta Agrawal ¹, D. K. Tripathi ¹, Ajazuddin ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, 490024, IN

Source

Research Journal of Pharmacy and Technology, Vol 10, No 4 (2017), Pagination: 1197-1203

Abstract

The objective of this review article is to discuss the potential of sodium alginate as a biopolymer in the formulation development and its allied applications. There is a growing trend in pharmaceutical in food industry to avoid the harsh condition in the preparation for administration to the body or for the storage purpose as it induce the side effects, instability or loss of therapeutic effect of the medicament. The immobilization method is a versatile functional biomaterial for viscosity enhancement, stabilizer, matrixing agent, encapsulation polymer, bio adhesive and film former in transdermal and transmucosal drug delivery. Among various tested methods of this process that make use of different enzyme-carrier interactions, immobilization by adsorption on solid carriers has appeared most common. According to these findings, in this review we present a comparative analysis of the literature reports on the recent trends in the immobilization of the enzymes by adsorption. In this review article, the various aspects of pharmaceutical microemulsin where compile together and the target audience are specifically the M. Pharm and B. Pharm student so that their knowledge towards the subject concern can be enhanced and also at the same time can be motivated towards the publication.

Keywords

Immobilization, Adsorption, Cross Linking, Microencapsulation.

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• Emphasizing the Pharmaceutical Consideration behind the Development of Gastro-Retentive Dosage form

Abstract Views :148  |  PDF Views:1

Authors

Rita Devi ¹, Vicky Soni ¹, Savej Malik ¹, Alok Singh ¹, Kundan Banjare ¹, Vikram Singh ¹, Tanuja Janghel ¹, Pooja Pal ¹, Mukta Agrawal ¹, D. K. Tripathi ¹, Ajazuddin ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, 490024, IN

Source

Research Journal of Pharmacy and Technology, Vol 10, No 4 (2017), Pagination: 1209-1214

Abstract

Recent technological and scientific research has been devoted to the development of rate controlled drug delivery systems to overcome physiological adversities such as short gastric residence times and unpredictable gastric emptying times. The floating or hydro-dynamically controlled drug delivery systems are useful in such application. The objective of our review is to compile the recent advancements and developments regarding the novel dosage form i.e. the floating drug delivery systems (FDDS) that can be retained in the stomach for a prolonged period of time and gives therapeutic action in a predetermined manner. In these review article,the various aspects of pharmaceutical floating drug delivery system(FDDS) were compiled together and the target ordinance are specifically the M. Pharm and B Pharm students so that their knowledge towards the subject concern can be enhanced and also at the same time can be motivated towards the publication.

Keywords

Gastric Retention, Oral Controlled Release System, Gastric Resistance, Emptying Time, FDDS.

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• Pharmaceutical Considerations behind the Development and Evaluation of Mucoadhesive Tablets

Abstract Views :137  |  PDF Views:1

Authors

Rashmi Verma ¹, Yamini Dewangan ¹, Lokeshwari Sahu ¹, Barkha Dongre ¹, Khushboo Mishra ¹, Trilok Patel ¹, Sakhram Nishad ¹, Ashish Damle ¹, Ghanshyam Sahu ¹, K. DeviRao ¹, Mithlesh Patle ¹, Mukta Agrawal ¹, D. K. Tripathi ¹, Ajazuddin ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, 490024, IN

Source

Research Journal of Pharmacy and Technology, Vol 10, No 4 (2017), Pagination: 1230-1238

Abstract

The current article has been focused on the Mucoadhesive drug delivery system may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome. Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first-pass metabolism. The Mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. This review article aims to provide an overview of the various aspects of mucoadhesion, Mucoadhesive materials, factors affecting mucoadhesion, evaluating methods, and finally various Mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal) based on literatures were reported so far. In this review article, the various aspects of pharmaceutical microemulsion were compiled together and the target audiences are specifically the M. Pharm and B. Pharm students so that their knowledge towards the subject concern can be enhanced and also at the same time can be motivated towards the publication.

Keywords

Bioadhesive, Transmucosal, Absorption.

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• Underlining the Pharmaceutical Aspects Associated with the Development of pH Responsive Hydrogel

Abstract Views :145  |  PDF Views:1

Authors

Anubhav Mishra ¹, Girish Sahu ¹, Amit Kumar ¹, Deepak Patel ¹, Ghanshyam Rathore ¹, Dileshwar Sahu ¹, Ravindra ¹, Manmohan Diwan ¹, Dhaniram Kanwar ¹, Laxminarayan Patel ¹, Mukta Agrawal ¹, D. K. Tripathi ¹, Ajazuddin ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, 490024, IN

Source

Research Journal of Pharmacy and Technology, Vol 10, No 4 (2017), Pagination: 1261-1268

Abstract

Controlled drug delivery is useful because it allows obtaining better drug product, effectiveness, reliability and safety. Hydrogel are one of the upcoming classes of polymer-based controlled release drug delivery systems. Besides exhibiting swelling-controlled drug release, hydrogel also show stimuli-responsive changes in their structural network and hence, the drug release. Because of large variations in physiological pH at various body sites in normal as well as pathological conditions, pH-responsive polymeric networks have been extensively studied. This review highlights the use of hydrogel (a class of polymeric systems) in controlled drug delivery, and their application in pH-responsive, drug release. Hydrogel show minimal tendency to adsorb proteins from body fluids because of their low interfacial tension. Further, the ability of molecules of different sizes to diffuse into (drug loading) and out of (drug release) hydrogel allows the possible use of dry or swollen polymeric networks as drug delivery systems for oral, nasal, buccal, rectal, vaginal, ocular and parenteral routes of administration. Hydrogel also terms 'intelligent gels' or 'smart hydrogel'. The smartness of any material is the key to its ability to receive, transmit or process a stimulus, and respond by producing a useful effect. This review highlights the use of hydrogel (a class of polymeric systems) in controlled drug delivery, and their application in stimuli responsive, especially pH-responsive, drug release. In this review article, the various aspects of pharmaceutical microemulsin where compile together and the target audience are specifically the M.pharm and B.pharm student so that their knowledge towards the subject concern can be enhanced and also at the same time can be motivated towards the publication.

Keywords

Hydrogel, Stimuli-Responsive, Smart Hydrogel.

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• Formulation Aspects behind the Development of a Stable Biphasic Liquid Dosage Form with Special Reference to Microemulsion

Abstract Views :175  |  PDF Views:1

Authors

Shriya Gupta ¹, Sonali Dhokne ¹, Rameshwar Verma ¹, Manish Mitra ¹, Umesh Sahu ¹, Pitamber Bhardwaj ¹, Mohainish Bhoyar ¹, Manoj Biswas ¹, Lukesh Sahu ¹, Sheetal Jha ¹, Mukta Agrawal ¹, D. K. Tripathi ¹, Ajazuddin ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh 490024, IN

Source

Research Journal of Pharmacy and Technology, Vol 10, No 5 (2017), Pagination: 1509-1516

Abstract

Biphasic liquid dosage have an associated limitation of poor physical stability and therefore it is said to be thermodynamically unstable. Moreover, this area is also of great interest among the researchers towards the improvement of the stability. Thus, development of microemulsion systems is of great interest among the researchers. A microemulsion is a system of water, oil and amphiphilic compounds (surfactant and co-surfactant) which is a transparent, single opticalisotropic and thermodynamical stable liquid. Microemulsions are readily distinguished from normal emulsions by their transparency, low viscosity and more fundamentally their thermodynamic stability. In this review article, the various aspects of pharmaceutical microemulsion were compiled together and the target audiences are specifically the M. Pharm and B. Pharm students so that their knowledge towards the subject concern can be enhanced and also at the same time can be motivated towards the publication.

Keywords

Microemulsion, Transparency, Amphiphilic.

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• An Exhaustive Review Based on the Formulation and Evaluation Methods behind the Development of Transdermal Drug Delivery Systems

Abstract Views :213  |  PDF Views:1

Authors

Archana Kushwaha ¹, Jayanti Jaiswal ¹, Priya Singh ¹, Neha Rathore ¹, Jai Prakash Dhruw ¹, Ishu Sahu ¹, Chhaya Singh ¹, Krinsha Kumar Sahu ¹, Mukta Agrawal ¹, D. K. Tripathi ¹, Ajazuddin ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh 490024, IN

Source

Research Journal of Pharmacy and Technology, Vol 10, No 5 (2017), Pagination: 1531-1538

Abstract

Transdermal drug delivery systems (TDDS) are dosage forms involves drug transport to viable epidermal and or dermal tissues of the skin for local therapeutic effect while a main function of drug is transported into the systemic blood circulation. The purpose of this research was to develop a matrix-type transdermal therapeutic system containing drug diclofenac with different ratios of hydrophilic (hydroxyl propyl cellulose) and hydrophobic (ethyl cellulose) polymeric systems polymeric systems by the solvent evaporation technique and by using Glycerol as plasticizer. Different concentrations of oleic acid and isopropyl myristate were used to enhance the transdermal permeation of Diclofenac. To improve characters of transdermal drug delivery system (TDDS) was emerged, which will improve the therapeutic efficacy and safety of drugs by specific sites within the body, thereby reducing both the size and number of doses. The present article reviews the selection of drug candidates and polymers suitable to be formulated as transdermal system, advantages, disadvantages of formulation design and the methods of evaluation. In this review article the various aspects of pharmaceutical transdermal drug delivery system where compiled together and the target audience are specifically the M Pharm and B Pharm students so that their knowledge towards the subject concern can be enhanced and also at the same time can be motivated towards the publications.

Keywords

Transdermal Drug Delivery System Diclofenac, Transdermal Film, Permeation Enhancer.

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• Review on the Formulation Considerations Needed to Produce a Stable Self Micro Emulsifying Drug Delivery System (SMEDDS)

Abstract Views :179  |  PDF Views:1

Authors

Ashok Chandrakar ¹, Bishesar Sahu ¹, Homendra Sahu ¹, Jagdish Dewangan ¹, Navin Kumar ¹, Rajat Singh ¹, Rohit Gupta ¹, Devesh Kumar ¹, Bhishm Sahu ¹, Kuldeep Dewangan ¹, Rishi Kaushal ¹, Mukta Agrawal ¹, D. K. Tripathi ¹, Ajazuddin ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh 490024, IN

Source

Research Journal of Pharmacy and Technology, Vol 10, No 5 (2017), Pagination: 1563-1570

Abstract

Ease of administration and painless approach made oral route the most preferred. Poor oral bioavailability is pronounced with the majority of recent active ingredients because of dissolution rate limited absorption. Failure to attain intended therapeutic effect of the poor water soluble drugs by this route led to development of novel drug delivery systems which will fulfill therapeutic needs with minimum dose. Although many formulation approaches like solid dispersions, complexation, pH modifications and lipid based delivery systems finding increased appliance with the apparent increase in absorption of drug. Among lipid based formulations, self-micro emulsifying formulations (droplet size < 100 nm) are evident to improve the oral bioavailability of hydrophobic drugs primarily due to their efficiency in facilitating solubilization and in presenting the hydrophobic drug in solubilized form whereby dissolution process can be circumvented. Various components that are used to formulate these dosage forms like surfactants and lipids contribute to the overall improvement in oral bioavailability via promoting the lymphatic transport; thereby hepatic first pass metabolism can be surmounted. The present article gives exhaustive information on the formulation design and characterization of SMEDDS by which the bioavailability can be improved. In this review article, the various aspects of pharmaceutical SMEDDS where compiled together and target audience are specifically the B.Pharm and M.Pharm students so that their knowledge towards the subject concern can be enhanced and also at the same time can be motivated towards the publication.

Keywords

SMEDDS, Solubilization, Emulsion, Stability, Surfactant.

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• Enzyme Immobilization: A Bridge of Understanding between Biotechnology and Pharmacy

Abstract Views :452  |  PDF Views:0

Authors

Nisha Nair ¹, Amrita Thakur ¹, Mukta Agrawal ¹, Juhi Thakur ¹, Shubhangi Gupta ¹, Bharti Sahu ¹, Devendra Kumar ¹, Indu Rai ¹, Jaya Sonkar ¹, Kalyani Sahu ¹, Kuldeep ¹, Kailash Kumar ¹, Muktanand ¹, Nidhi Kaushik ¹, Omkar Sahu ¹, Somsunder Sahu ¹, Umesh Kumar ¹, D. K. Tripathi ¹, Ajazuddin ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, IN

Source

Research Journal of Pharmaceutical Dosage Form and Technology, Vol 10, No 2 (2018), Pagination: 109-113

Abstract

As the demands of world biotechnology and pharmaceutical industries have increased, a need to develop and enhance, reaction stability, reusability and shelf life of enzymes has also become necessary. Hence noveltechnologies are needed to facilitate large-scale and economic formulations. Enzyme immobilization is a technique most apt to meet all the challenges in regards to enzyme activity. It provides immensescope for increasing availability of enzyme to the substrate and also increases product turn over, also increases the efficiency of an enzyme to a great extent. Immobilization of enzyme can be done by entrapment, support binding, cross-linking of enzyme crystals, etc. For immobilization, numerous natural and synthetic support materials are used. Nowadays, immobilized enzymes are much more preferred rather than their free counterpart because of their prolonged availability. Immobilized enzymesare widely used in pharmaceutical industries, cosmetic industries, food processing, biofuel production and many other sectors. The present study is performed for the motivation of the graduates towards publication and research. Hence, we have encouraged the graduates to prepare an informative article on the current subject.

Keywords

Immobilization, Adsorption, Cross-Linking, Microencapsulation, Covalent Bonding.

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References

• Mathiowitz E, Chickering D, Jacob JS, Santos C. Bioadhesive drug delivery systems. Encyclopedia of Controlled Drug Delivery. Vol. 1. New York: Wiley; 1999. p. 9-44.
• Hong X, Wei L, Ma L, Chen Y, Liu Z, Yuan W. Novel preparation method for sustained-release PLGA microspheres using water-inoilin-hydrophilic-oil-inwater emulsion. Int J Nanomedicine 2013; 8:2 433-41.
• Jorgensen L, Moeller EH, van de Weert M, Nielsen HM, Frokjaer S. Preparing and evaluating delivery systems for proteins. Eur J Pharm Sci 2006; 29: 174-82.
• Castellanos IJ, Cruz G, Crespo R, Griebenow K. Encapsulation induced aggregation and loss in activity of gamma-chymotrypsin and their prevention. J Control Release 2002;81:307-19.
• Ceriello A. The emerging role of post-prandial hyperglycaemic spikes in the pathogenesis of diabetic complications. Diabet Med 1998; 15: 188-93.
• Dabhi AS. Voglibose: An alpha-glucosidase inhibitor. Clin Diagn Res 2013; 7: 3023-7.
• Deruiter J. Overview of the antidiabetic agents. Endocr Pharmacother Module Spring 2003; 25: 1-33.
• Voglibose. Japanese Pharmacopeia. XV Official Monographs. 2006. p. 1231.
• Rao NM. Development and validation.
• SM Sarode, G Vidya Sagar, MK Kale, Nimase PK, Kulkarni AP, Firke SD,Firke BM, Warke PD, Chaudhari MA. Preparation and Evaluation of Floating Calcium Alginate Beads of Clarithromycin. Research J. Pharma. Dosage Forms and Tech. 2010; 2(2): 173-177.
• Kulkarni SJ. Enzyme immobilization: research and studies. Int J Res Rev. 2016; 3(7): 31-35.
• Aehle, W. Enzymes in Industry (Third edition), 2007 Wiley-VCH, ISBN 978-3-527-31689-2, Weinheim
• Literature Survey Methods in Biotechnology: Immobilization of Enzymes and Cells, 2006, 2^nd (Ed.), 15-30.
• Costa, S. A.; Azevedo, H. S. and Reis, R. L. Enzymeimmobilization in biodegradable polymers for biomedical applications, In:Biodegradable systemsin tissue engineering and regenerative medicine. R.L. Reis and J. S. Román, (Ed.), 2005, CRC PressLLC, ISBN 978- 0-203-49123-2, London
• Guisan, J. M. Immobilization of enzymes as the 21st century begins, In: Immobilization of enzymesand cells. (Second edition), J. M. Guisan, (Ed.), 2009 Humana Press Inc., ISBN 1-597450537, New Jersey
• Sheldon, R. A. Enzyme immobilization: The quest for optimum performance. Advanced Synthesis and Catalysis. 2007, Vol. 349, No. 8-9, pp. 1289-1307, ISSN 1615-4169
• Cao, L. Carrier-bound immobilized enzymes, Principles, Application and Design (first edition), 2005, Wiley-VCH, ISBN 978-1-61583-208-8, Weinheim
• Hernandez, K. and Fernandez-Lafuente, R, Enzymeand Microbial Technology, 2011, Vol. 48, No. 2, pp. 107-122, ISSN 0141-0229
• Krajewska B. Enzyme and Microbial Technology,2004, Vol. 35, No. 2-3, pp. 126-139, ISSN 01410229
• Nelson J M, Griffin E G: Adsorption of Invertase, JAm Chem Soc 1916, 38: 1109-1115.
• N. Grubhofer and N Schelth , Nature, 1953, 4, 508.
• Harkins WD, Fourt L, Fourt PC. J Biol Chem 1940,132:111–118
• Gale EF, Epps MR, Biochem J 1944, 38:232–242
• Langmuir I, Schaefer VJ, J Am Chem Soc 1938, 60:1351–1360
• Persson M, Bulow L, Mosbach K, FEBS Lett 1990, 270:41–44 26. Wang P, Sergeeva MV, Lim L, Dordick JS. Nat Biotechnol 1997, 15:789–793
• Dordick JS, Novick SJ, Sergeeva MV. Chem Ind (London) 1998, 17–20
• .Matoba S, Tsuneda S, Saito K, Sugo T,Bio/Technology 1995, 13:795–797
• Kim J, H. Jia, C W. Lee, S W. Chung, Enz and Microb Technol. Vol 39, issue 3, 474-480, 2006
• Kim J, Grate J W. and P Wang. Nanobiocatalysis and its potential applications, 2008, cell press, 639-646, 10.1016.
• Wong LS, Thirlway J, Micklefield J. J. Am. Chem. Soc.2008 130(37): 12456-12464.
• Ghous T, Jn chem. Soc. Pak. Vol23, 4, 2001.
• Porath, J. and Axén, R. 1953: Methods in Enzymology, volume XLIV, (Mosbach, K., ed.), Academic Press, New York, NY, pp. 19-45.
• Chae, H.J. et al, Appl. Biochem. Biotechnol. 1998.73, 195.
• Quirk, R.A. et al, Biomaterials, 2001, 22, 865.
• Bernfeld P. and Wan J. Antigens and enzymes made insoluble by entrapping them into the lattices of synthetic polymers science 1963, 142, 678-679.
• Riaz A, Qader S, Anwar A, Iqbal S, Aust. J. Basicand Appl. 2009 Sci. 3, 2883.

• Formulation Aspects Behind the Development of a Stable Biphasic Liquid Dosage Form with Special Reference to Microemulsion: A Review

Abstract Views :460  |  PDF Views:0

Authors

Amrita Thakur ¹, Nisha Nair ¹, Mukta Agrawal ¹, Yashi Thakur ¹, Juhi Thakur ¹, Teman Nirmalkar ¹, Ved Prakash Verma ¹, Vibhash Gupta ¹, Vivek Singh Yadav ¹, Kalpana Mahilange ¹, Pooja Mahant ¹, Pritam Yadav ¹, Deepak Patel ¹, Dinesh Khamari ¹, Jyotsana Meshram ¹, Rakesh Sahu ¹, Tarun Ghatode ¹, D. K. Tripathi ¹, Ajazuddin ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, IN

Source

Research Journal of Pharmaceutical Dosage Form and Technology, Vol 10, No 2 (2018), Pagination: 114-118

Abstract

A plethora of research and industrial processes used microemulsion system after its discovery by Jack H. Shulman. The microemulsionis defined as clear, stable, isotropic mixtures of oil, water, and surfactant, frequently in combination with a co-surfactant. They are solutions of oil, water,andamphiphile which are optically isotropic and thermodynamically stable. The aqueous phase present in the system contains salt(s) and other ingredients while the "oil" phase mainly forms a complex of different hydrocarbons and olefins. They do not require high shear conditions as compared to ordinary emulsions. Hence they are easy to prepare. Ultralow interfacial tension, large interfacial area, thermodynamic stability and the ability to solubilize immiscible liquids are some of its unique properties. They also show the ability to protect labile drug, control drug release, increase drug solubility, increase bioavailability and reduce patient variability. Hence, microemulsion has gained most significance in both basictypes of research as well as in industry. They have wide applications and uses such as in pharmaceuticals, cosmetics, cutting oils, biotechnology, food, agrochemicals, environmental detoxification, analytical applications, microporous media synthesis, etc. The microemulsion can be effectively used in dermal delivery because of its mechanism, hence can be used in pharmaceutical and cosmetics preparation. Microemulsion enhances the dermal absorption as they allow rapid penetration of active molecules due to the large surface area of the internal phase and their components reduce the barrier of stratum corneum. Thus, microemulsionisa promising vehicle for effective drug delivery. The current review article deals with information about the microemulsion. Also, the present study is performed for the motivation of the graduates towards publication and research. Hence, we have encouraged the graduates to prepare an informative article on the present subject.

Keywords

Microemulsion, Thermodynamically Stable, Bioavailability.

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References

• T.P. Hoar and J.H. Schulman. Transparent water-in-oil dispersions, the oleopathic hydro micelle. Nature 1943; 152: 102-103.
• J. H. Schulman et al. Mechanism of formation and structure of micro emulsions by electron microscopy. The Journal of Physical Chemistry 1959; 63: 1677-1680.
• Danielsson and B. Lindman. The definition of a microemulsion, Colloids and Surfaces 1981; 3: 391–392.
• Shinoda K and Lindman B. Organised surfactant systems: Microemulsions. Langmuir 1987; 3: 135–149.
• M. Jayne Lawrencea and Gareth D. Reesb. Microemulsion-based media as novel drug delivery systems. Advanced Drug Delivery Reviews 2000; 45: 89–121.
• Kumar. K. Senthil, Dhachinamoorthi. D, Saravanan. R; Microemulsions as Carrier for Novel Drug Delivery: A Review; International Journal of Pharmaceutical Sciences Review and Research., 10 (2011) 37-45.
• Patel R. Mrunali, Microemulsions: As Novel Drug Delivery Vehicle., 5 ( 2007).
• Madhav. S, Gupta. D, A review on microemulsion based system, IJPSR., 2(8) ( 2011) 1888-1899.
• Kunieda H. et al. The Journal of Physical Chemistry 1988; 92: 185.
• Mukherjee K. et al. Journal of Colloid and Interface Science 1997; 187: 327.
• Aboofazeli R and Lawrence M.J. Investigations into the formation and characterization of phospholipid microemulsions. I. Pseudoternary phase diagrams of systems containing waterlecithinalcohol-isopropyl myristate. International Journal of Pharmaceutics 1993; 93: 161-175.
• JhaSajal Kumar et al. Microemulsions- Potential Carrier for Improved Drug Delivery. InternationalePharmaceuticaSciencia 2011;1(2): 25-31.
• Kumar P, Mittal KL. Handbook of Micro emulsion Science and Technology; 1st Edn; CRC Press, New York, 1999.
• Tenjarla S. Microemulsions: an overview and pharmaceutical applications. CritRevTher Drug Carrier Syst. 1999; 16(5): 461 521.
• Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev. 2000; 45(1): 89-121.
• Muzaffar F, Singh U, ChauhanL.Review on microemulsion as futuristic drug delivery.Int J Pharm Pharm Sci. 2013; 5(3); 39-53.
• Rajput R, Kumar V, Sharma S. Microemulsions: Current trends in sustained release drug delivery systems.International Journal of PharmaProfessional’s Research. 2016; 7(1); 1326-1332.
• Park K M and Kim C K. Preparation and evaluation of flurbiprofen loaded Microemulsions for parental delivery. International Journal of Pharmaceutics 1999; 181: 173-179.
• Bhaskar Bangar, Namdeo Shinde, Sunil Deshmukh, Birudev Kale. Natural Polymers in Drug Delivery Development. Res. J. Pharm. Dosage Form. and Tech. 6(1): Jan.-Mar. 2014; Page 54-57.
• Venkatesh Gavini, M. Srinivasa Murthy, P. Kiran Kumar. Formulation and Invitro Evaluation of Nanoparticulate Drug Delivery System Loaded With 5-Fluorouracil. Res. J. Pharm. Dosage Form. and Tech. 6(4):Oct-Dec.2014; Page 243-248.
• Bhaskar Kurangi, SandeshSomnache, NileshJangade. Micellar Drug Delivery System. Res. J. Pharm. Dosage Form. and Tech. 6(4):Oct.- Dec.2014; Page 267-281.
• Amol S. Deshmukh. Solid Lipid Nanoparticles.Res. J. Pharm. Dosage Form. and Tech. 6(4):Oct-Dec.2014; Page 282-285.
• Mahendra Deshpande, Chandrashekhara S, Nagesh C., Mitul Patel, Sandip Patel ,Vivek Majethiya. Enhancement of Solubility of Trimethoprim IP by Using Different Surfactants. Research J. Pharma. Dosage Forms and Tech. 2012; 4(1): 48-51.

• A Review on Biocompatible Hydrogel: Formulation Aspect and Evaluation

Abstract Views :502  |  PDF Views:0

Authors

Shubham Tripathi ¹, Somnath Patel ¹, Ritesh Patel ¹, Shraddha ¹, Pushpendra ¹, Sachin ¹, Neetish ¹, Mahendra ¹, Kuldeep ¹, Prashant ¹, Rajesh Patel ¹, Girish ¹, Nitin ¹, Tomanlal ¹, Amrita Thakur ¹, Mukta Agrawal ¹, Ajazuddin ¹, D. K. Tripathi ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, IN

Source

Research Journal of Pharmaceutical Dosage Form and Technology, Vol 10, No 2 (2018), Pagination: 119-122

Abstract

Many predefined ways are now a day adopted to interface with biological tissues. One such significant class of biomaterials are hydrogels, which are defined as highly hydrated materials. Hydrogels are designed to absorb a large amount of water or biological fluids due to its three-dimensional, hydrophilic, polymeric network. They closely simulate natural living tissue, more so than any other class of synthetic biomaterials because of their high-water content, porosity,and soft consistency.They are chemically stable but may degrade and gradually disintegrate up to dissolve. Now a day they become more popular because of their unique property of flexibility and biocompatibility. Hydrogels can be produced by both natural and synthetic polymers. These polymers undergo physical and chemical cross-linking to produce hydrogels. Due to their resemblance to the living tissue, they have the immense possibility to use hydrogels in the biomedical field. Some of the well-known use of hydrogels include manufacturing contact lenses, hygiene products, tissue engineering scaffolds, drug delivery system and wound dressings. The current review article deals with information about the hydrogels, their various types, preparation methods along with an evaluation of the same.Also, the present study is performed for the motivation of the graduates towards publication and research. Hence, we have encouraged the graduates to prepare an informative article on the present subject.

Keywords

Hydrogel, Polymeric Network, Porosity, Biocompatibility, Biomedical.

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References

• Caló E, Khutoryanskiy VV.Biomedical Applications Of Hydrogels: A Review Of Patents And Commercial Products, European Polymer Journal. 2015; 65: 252-267.
• Das N. Preparation Methods And Properties Of Hydrogels: A Review. International Journal of Pharmacy and Pharmaceutical Sciences. 2013; 5(3): 112-117.
• Hoare TR, Kohane DS. Hydrogels In Drug Delivery: Progress And Challenges. Polymer. 2008; 49(8): 1993-2007.
• Phadke A, Zhang C, Arman B, ChengChih Hsu, Mashelkar R. Lele A, Tauber M, Arya G,andVarghese S.Rapid Self-Healing Hydrogels.Proceedings of the National Academy of Sciences. 2012; 109: 4383-4388.
• Dwivedi S, Khatri P, Mehra GR,Kumar V. Hydrogel-A Conceptual Overview. International Journal of Pharmaceutical and Biological Archives. 2011; 2(6): 1588-1597.
• Ahmed EM. Hydrogel: Preparation, Characterization And Applications. Journal of advanced research. 2015; 6(2): 105-121.
• Iizawa T, Taketa H, Maruta M, Ishido T, Gotoh T, Sakohara S. Synthesis of porous poly (N-isopropylacrylamide) gel beads by sedimentation polymerization and their morphology. Journal of applied polymer. 2007; 104: 842-850.
• Singh SK, Dhyani A,Juyal D. Hydrogel: Preparation, Characterization And Applications. The Pharma Innovation Journal. 2017; 6(6): 25-32.
• Himi M, Maurya SD, Preparation and Evaluation Of Stomach Specific IPN Hydrogels For Oral Drug Delivery: A Review. Journal of Drug Delivery and Therapeutics. 2013, 3(2), 131-140.
• Swarbrick J, Encyclopedia Of Pharmaceutics, 4th edition,Vol III, F-O, 6000 Broken Sound Parkway NW, Suite300, Boca Raton, FL 33487-2742, Taylor and Francis Group,, 2013.
• Bindu M, Ashok. V, Chatterjee A. Review Article As A Review On Hydrogels As Drug Delivery In The Pharmaceutical Field. International Journal of pharm and chemical sciences ISSN: 2277: 5005: 642-661.
• Aulton M., Aulton’s pharmaceutics, The Design and Manufacture of Medicines, Third Edition, Elsevier’s Health Sciences Rights Department, 1600 John F. Kennedy Boulevard, Suite 1800, Philadelphia, PA 19103-2899, Harcourt Publishers Limited 2001.
• Chien Y. Novel drug delivery systems. second edition, New York, 52 Vanderbuilt Avenue, Informa Healthcare USA, Inc, 2009.

• Formulation and Characterization of Virgin Coconut Oil Emulsion (VCOE) for Treatment of Alzheimer’s Disease

Abstract Views :530  |  PDF Views:0

Authors

Shubham Tripathi ¹, Umesh Kumar Sahu ¹, Jyotsana Meshram ¹, Ranjeeta Kumari ¹, D. K. Tripathi ¹, Ajazuddin ¹, Amit Alexander ¹, Harish Sharma ², Gyanesh Kumar Sahu ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka Kurud Road, Bhilai, IN
2 Shri Shankaracharya technical campus, Shri Shankaracharya group of institution, Faculty of Pharmacy, Junwani, Bhilai, IN

Source

Research Journal of Pharmaceutical Dosage Form and Technology, Vol 10, No 2 (2018), Pagination: 49-54

Abstract

Alzheimer’s disease, is a somatic disease that affects the brain. It is a progressive disease that destroys memory and other important mental functions. During this disease, accumulation of cerebral extracellular amyloid, which is mostly composed of accumulated amyloid-β (Ab) peptide as well as the accumulation of intracellular neurofibrillary tangles, appears to start up. This results in the loss of connection between nerve cell, and lead to the degeneration of neurons and finally death of brain tissue. Also due to the deficiency of some important chemical messenger in the brain, the signal transmission gets ultimately, affected in the body. The main objective of this study was to prepare the optimized formula of a VCO based emulsion containing Tween 20 as the surfactant for treatment of Alzheimer’s disease which may help to increase the cholesterol level in the brain and to destroy the β amyloid plaque as a result of which the level of chemical messenger will increase in the brain. This study is further aimed to analyze, concentration of drug reaching into the brain and to study its effect in destroying β amyloid plaque.

Keywords

Amyloid-β, Chemical Messengers, Neurofibrillary, Tangles, Peptide, Cholesterol.

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References

• Fernado W.M.A.D.B, Martin J, Goozee K.J, Brennan S. Charles, Jayasena V. and Martin R.N. Review article on the role of dietary coconut for the prevention and treatment of alzheimer’s disease: potential mechanisms of action, published on 22 may 2015.
• Cummings J, Schneider LS, Aisen PS "ymptomatic and nonamyloid based pharmacologic treatment for Alzheimer disease". Cold Spring Harb Perspect Med, vol. 2, 2012.
• Villemagne, Bourgeat,P., BurnhamV.L Brown, B., Ellis, K.A., Salvado, O. et al. Amyloid ßdeposition, neurodegeneration and cognitive decline in sporadic Alzheimer’s disease: A prospective cohort study. Lancet Neurol. 2013.
• Xiong, C., Benzinger, A.M., Goate, T.L., Bateman, R.J, Fagan, Clinical and biomarker changes in dominantly inherited Alzheimer’s disease. N Engl J Med. 2012.
• Alzheimer society, fact sheet, 40 1LP 2014, what is Alzheimer’s disease?
• Bourgeat P, Villemagne VL, Chetelat G, Relationship between atrophy and b-amyloid deposition in Alzheimer disease. Ann Neurol 2010.
• JA,, Luchsinger, Stern Y Mediterranean diet, inflammatory and metabolic biomarkers, and risk of Alzheimer's disease. 2010 8. Alzheimer’s Association. 2012 Alzheimer’s Disease Facts and Figures., vol. 8, no. 2, USA, 2012.
• J. Jauregui, with "severe dementia" returning to old self after starting coconut oil. www.hawkeshealth.net Mar 28, 2012.
• L. Johnson "Coconut oil touted as Alzheimer’s remedy". www.cbn.com/cbnnews/healthscience/2012/January/Coconut-oilTouted, 2012 Jan 5.
• KG Goozee, WMF Fernando, V Jayasena, IJ Martins, CS Brennan, RN Martins. The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action, 2015 Jul. (MOA).
• ST Henderson, Ketone bodies as a therapeutic for Alzheimer’s disease, Neuro therapeutics, vol.5, no. 3, pp. 47-80, 2008.
• Devere R. "Ketones-A New treatment for Alzheimer's disease?" Practical Neurology, www.practicalneurology.org, pp. 14-16.
• Keto-dementia Diet, #2 articles, www.centerwatch.com or druginformation.
• Segawa, E., Wilson, R.S., Boyle, P.A., Hizel, L.P., Anagnos, S.E., and Bennett, D.A. "The natural history of cognitive decline in Alzheimer’s disease" Psychol Aging. 2012.
• R. Katzman, "The prevalence and malignancy of Alzheimer disease: A major killer Arch Neurol" 1976.
• Sanjeewani N.A, Sakeena MHF, formulation and characterization of virgin coconut oil based emulsion (VCO), international journal of scientific and research publication, vol III, issue 12, December 2013.
• Wriyanilastri, Aladinandi, Yanisetyawati and Rahmawati, stability of coconut oil emulsion with mixed emulsifier tween 80 and span 80 ARPN journal of engineering and applied science, Vol II, No 8, April 2016. (emulsion)
• D. Divina, Bawalan D, processing manual for virgin coconut oil, its products and by-products for pacific island countries and territories
• Amin, A.M. Marina, Y.B. Che "Virgin coconut oil: emerging functional food oil", Trends in Food Science and Technology, Volume 20 (2009).
• Kappallyshijna, Shirwaikar Arun and Shirwaikar Anni, coconut oil-a review of potential application, Hygeia journal of drug and medicine march 2016".
• Ajit SB, Gaurav R, Gopala KAG. Coconut oil: chemistry, production and its applications–a review. Indian Coconut 2010.
• Y. C. Wong and H. Hartina, virgin coconut oil production by centrifugation method, Oriental journal of pharmacy, volume 30, number 1.
• Abdurahman H. Nour, F.S. mohammed, Rosli M. Yunus and A, Arman, demulsification of virgin coconut oil by centrifugation method ; a feasibility study, International journal of chemical technology, year 2009, vol I, page no 59-64.
• M.I. Ozhovan (1993), "Dynamic uniform fractals in emulsions" http://www.jetp.ac.ru/cgi-bin/dn/e_077_06_0939.pdf J. Exp.Theor. Phys. 77: 939–943.
• Subramanyam CBS, text book of physical pharmaceutics, vallabhprakashan, 2nd edition 2014, page no. 395-426.
• Tripathi D.K. a text book of industrial pharmacy, pharmamed press 2015, page no. 309-342.
• Lachmannliebermen, the theory and practice of industrial pharmacy, CBS publisher and distributer, 4^th edition 2013, page no. 686.
• Mehta R.M. pharmaceutics II, Niraliprakashan 15th edition 2010, page no. 11.1-11.20.
• A.M. Marina, Y.B. Man, Ismail A, virgin coconut oil; emerging functional food oil, article in trends in food science and technology, 20(10), 481-487, October 2009
• Harish sharma, Vaibhav Kumar Dapurkar, Dr. Gopalrai, Gyanesh Kumar Sahu, Microemulsionfor the topical administration of 5fluorouracil preparation and evaluation, Research journal of pharmaceutical tech 5(8), Aug 2012.
• VaibhavKumar Dapurkar, Harish Sharma, Gyanesh Kumar Sahu, Swati Meshram, Dr. GopalRai, Anti arthritic activity of ischolar_mains extract of boerhaaviadiffusa in adjuvant induced arthritis rats, Scholar academic journal of pharmacy 2013 2(2): 107-109.
• GyaneshKumar Sahu, Harish Sharma, Anshita Gupta, Chanchal Deep Kaur, A review article on advancement in microemulsion based drug delivery system for better therapeutic effect, International journal of pharmaceutical sciences and developmental research , Aug 2015.
• GyaneshKumar Sahu, Harish Sharma, VaibhavKumar Dapurkar, An over view of new drug delivery system: microemulsion, International research journal of pharmaceutical and applied science, 2012 2(5): 1-8
• GyaneshKumar Sahu, Harish Sharma, ChanchalDeep Kaur, Evolving concepts and targeting arthritis, World journal of pharmaceutical research, 26 may 2014, vol III, issue 4, 1960-1975.
• GyaneshKumar Sahu, Harish Sharma, ChanchalDeep Kaur, A novel approach of magnetic modulated microspheres, Asian J. of research, 2013, vol III, Issue 4, page 220-224.
• Gyaneshkumarsahu, Harish sharma, Dr. GopalRai, Vaibhav Kumar Dapurkar, Development and evaluation of methotreaxate loaded BSA microsphere, International research journal of pharmaceutical and applied science, 2012; 2(5); 9-12.
• Bony R. Shah, DhruboJyotiSen, Rajesh Bahekar. Design, Synthesis and Pharmacological Evaluation of Potent and Selective Dipeptidyl-Derived Inhibitors as New Class of Antidiabetic Drugs. Asian J. Research Chem. 4(1): January 2011; Page 50-54.
• SunitaSoni, Ajay Soni, Sunil Ganatra. Studies on the Optimum Reaction Time for Commercial Cholesterol kits. Asian J. Research Chem. 6(10): October 2013; Page 950-951.
• K. Hemalatha, V. Chakkaravarthi, K. Ganesa Murthy, R. Kayatri, K. Girija. Molecular Properties and Docking Studies of Benzimidazole Derivatives as Potential Peptide Deformylase Inhibitors. Asian J. Research Chem. 7(7): July 2014; Page 644-648.
• Rajesh Yadav, Nita. Yadav, MurliDharKharya. Steroid Chemistry and Steroid Hormone Action: A Review. Asian J. Research Chem. 7(11): November, 2014; Page 964-969.
• SandeepPokharia. An Atoms-in-molecules (AIM) interpretation of organotin-peptide system: I. Di-n-butyltin(IV) derivative of glycyltryptophane. Asian J. Research Chem. 2017; 10(2): 115-118.
• Gangadhara MM, Dinesha R, Satish Kumar Murari. A noncytotoxic pseudo peptide KL1 with potent antioxidant activity. Asian J. Research Chem. 2017; 10(2): 127-130.
• D. M. SuyogaVardhan, H. K. Kumara, H. Pavan Kumar, D. Channe Gowda. Urea and Thiourea Derivatives of Dipeptides Conjugated Piperazine Analogue as A New Class of AGE's Inhibitors: Synthesis and Molecular Docking Studies. Asian J. Research Chem. 2017; 10(4): 459-469.
• Pandey Rishabh, Singh AV, Pandey Awanish, Tripathi Poonam, SK Majumdar, Nath LK. Protein and Peptide Drugs: A Brief Review. Research J. Pharm. and Tech. 2(2): April-June. 2009; Page 228-233.

• Pharmaceutical Aspects on the Formulations of Hydrogel: An Update

Abstract Views :440  |  PDF Views:0

Authors

Ayushmaan Roy ¹, Anjali Wahane ¹, Siddharth Karankal ¹, Prachi Sharma ¹, Davesh Khutel ¹, Onkarnath Singh ¹, Vinay Shardul ¹, Pitamber ¹, Nausheen Sabha ¹, Jyoti Dewangan ¹, Ajay Dewangan ¹, Akash Jangde ¹, Chaya Rani ¹, Tekeshwar Sahu ¹, D. K. Tripathi ¹, Mukta Agrawal ¹, Ajazuddin ¹, Gyanesh Sahu ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, IN

Source

Research Journal of Pharmaceutical Dosage Form and Technology, Vol 10, No 2 (2018), Pagination: 79-84

Abstract

Hydrogels belongs to the classes of 3-dimensional cross-related polymer's community which could withstand the wide varieties of environmental fluctuations. These biomaterials can include massive quantum of biological fluids with extraordinaryswelling properties. whilst swelled, they exhibit opportune biocompatibility. Nowadays drug delivery enjoys several demanding situations where hydrogel might be onedeserving answer to those. Thanks to the specific properties of hydrogel for which they're employed except ionally in the field of biomedical sciences. For this reason, the raining techniques of hydrogel biomaterial and the evaluation of the different classes of above mentioned are most importance. literature's survey suggested that this 3-dimensional structure may be homo-polymeric, co-polymeric, andinterpenetrating polymer networks (IPN) based on guidance techniques. Polymericblends like semi-IPN have additionally been investigated to meet the precise requirements of biomedical science. Particularly emphasizing on biocompatibility, However, bendy strategies of synthesis and tailor in a posit ion physical residencehad made the hydrogels to be used as a drug transport tool in issue engineering. As scaffolds, they also offer structural integrity like tissues regeneration andrepair and as a drug carrier it must have enough mechanical strength to maintain the structural integrity of drug moiety. In this review article a comprehensiveapproach has been made to describe the strategies of hydrogel synthesis withtheir inevitable properties.the present study is performed for the motivation of the graduates towards publication and research. Hence, we have encouraged the graduates to prepare an informative article on the present subject.

Keywords

Hydrogel, Homo-polymer, Co-Polymer, Interpenetrating Network, Swelling, Mechanical, Biocompatible.

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References

• Prashant PK, Vivek BR, Deepashree ND, Pranav PP. Hydrogels as a drug delivery system and applications: a review. Int JPharm Pharm Sci. 2012; 4: 1-7.
• Das N, Bera T, Mukherjee A. Biomaterial hydrogels for different biomedical applications. Int J Pharm Bio Sci. 2012; 3: 586-595.
• Oh SB, Choi YK, Cho CS. Thermoplastic hydrogel based on pentablock copolymer consisting of poly(γ-benzyl L-glutamate) and poloxamer. J Appl Polym Sci. 2003; 88: 2649-2656.
• Isiklan N. Controlled release of insecticide carbaryl from sodium alginate, sodium alginate/gelatin, and sodium alginate/sodium carboxymethyl cellulose blend beads crosslinked with glutaraldehyde. J Appl Polym Sci. 2006; 99: 1310-1319.
• Zhang JT, Bhat R, Jandt KD. Temperature-sensitive PVA/PNIPAAm semi-IPN hydrogels with enhanced responsive properties. Acta Biomater. 2009; 5: 488-497.
• Krishna Rao KSV, Vijaya Kumar NB, Subha MCS, Sairam M, Aminabhavi TM. Novel chitosan-based pH-sensitive interpenetrating network microgels for the controlled release of cefadroxil. Carbohydr Polym. 2006; 66: 333-344.
• Iizawa T, Taketa H, Maruta M, Ishido T, Gotoh T, Sakohara S. Synthesis of porous poly (N-isopropylacrylamide) gel beads by sedimentation polymerization and their morphology. J Appl Polym Sci. 2007; 104: 842-850.
• Sykova E, Jendelova P, Urdzikova L, Lesny P, Hejcl A. Bone marrow stem cells and polymer hydrogels-two strategies for spinal cord injury repair. Cell Mol Neu robiol. 2006; 26: 1111-1127.
• Kubinova S, Horak D, Kozubenko N, Vanecek V, Proks V, Price Jet al. The use of superporous Ac-CGGASIKVAVS-OH modified PHEMA scaffolds to promote cell adhesion and the differentiation of human fetal neural precursors. Biomaterials 2010; 31: 5966-5975.
• Bavaresco VP, Zavaglia CAC, Reis MC, Gomes JR. Study on the tribological properties of pHEMA hydrogels for use in artificial articular cartilage. Wear 2008; 265: 269-277.
• Cretu A, Gattin R, Brachais L, Barbier-Baudry D. Synthesis and degradation of poly (2-hydroxyethyl methacrylate)-graft-poly (εcaprolactone) copolymers. Polym Degrad Stab. 2004; 83:399403.
• Gong CY, Shi S, Dong PW, Kan B, Gou ML, Wang XH et al. Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel. Int J Pharm. 2009; 365: 89-99.
• Lin CC, Anseth KS. PEG hydrogels for the controlled release of biomolecules in regenerative medicine. Pharm Res. 2009; 26:631-643.
• Kim B, Peppas NA. Poly(ethylene glycol)-containing hydrogels for oral protein delivery applications. Biomed Microdevices 2003; 5: 333-341.
• Benamer S, Mahlous M, Boukrif A, Mansouri B, Youcef SL.Synthesis and characterisation of hydrogels based on poly(vinyl pyrrolidone). Nucl Instrum Methods Phys Res. 2006; 248: 284-290.
• Christensen L, Breiting V, Vuust J, Hogdall E. Adverse reactions following injection with a permanent facial filler polyacrylamide hydrogel (aquamid): causes and treatment. Eur J Plast Surg. 2006; 28: 464-471.
• Cascone MG, Lazzeri L, Sparvoli E, Scatena M, Serino LP, Danti S. Morphological evaluation of bioartificial hydrogels as potential tissue engineering scaffolds. J Mater Sci Mater Med. 2004; 15: 1309-1313.
• Lugao AB, Rogero SO, Malmonge SM. Rheological behaviour of irradiated wound dressing poly(vinyl pyrrolidone) hydrogels. Radiat Phys Chem. 2002; 63: 543-546.
• Wang M, Xu L, Hu H, Zhai M, Peng J, Nho Y et al. Radiation synthesis of PVP/CMC hydrogels as wound dressing. Nucl Instrum Methods Phys Res. 2007; 265: 385-389.
• Thomas V, Yallapu MM, Sreedhar B, Bajpai SK. A versatile strategy to fabricate hydrogel-silver nanocomposites and investigation of their antimicrobial activity. J Colloid Interface Sci. 2007; 315: 389-395.
• Zhang YX, Wu FP, Li MZ, Wang EJ. pH switching on-off semiIPN hydrogel based on cross-linked poly(acrylamide-co-acrylic acid) and linear polyallyamine. Polymer 2005; 46: 7695-7700.
• Murthy PSK, Murali Mohan Y, Varaprasad K, Sreedhar B, Mohana Raju K. First successful design of semi-IPN hydrogelsilver nanocomposites: a facile approach for antibacterial application. J Colloid Interface Sci. 2008; 318: 217-224
• Gils PS, Ray D, Sahoo PK. Designing of silver nanoparticles in gum arabic based semi-IPN hydrogel. Int J Biol Macromol. 2010; 46: 237-244.
• Ju HK, Kim SY, Kim SJ, Lee YM. pH/temperature-responsive semi-IPN hydrogels composed of alginate and poly(N-isopropylacrylamide). J Appl Polym Sci. 2002; 83: 1128-1139

• A Comprehensive Note on Gastro-Retentive Dosage Forms

Abstract Views :513  |  PDF Views:0

Authors

Priya Patel ¹, Rohini Sahu ¹, Renjil Joshi ¹, Surabhi Armarkar ¹, Tarannum Parveen ¹, Narendra Pratap ¹, Renuka Sahu ¹, Pushpanjali Sahu ¹, Dujram Sahu ¹, Rupali Manikpuri ¹, Madhav Patel ¹, Tikeshwar Sahu ¹, Bhupendra Rajak ¹, Parmanand Sahu ¹, Pooja Yadav ¹, Mukta Agrawal ¹, Ajazuddin ¹, D. K. Tripathi ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, IN

Source

Research Journal of Pharmaceutical Dosage Form and Technology, Vol 10, No 2 (2018), Pagination: 85-89

Abstract

Controlled release drug delivery system has achieved greater importance in the field of pharmaceutical sciences to provide therapeutic advantages over the conventional drug delivery system. Nowadays, the gastrointestinal controlled drug delivery system is more prominent than the controlled release system because these can govern the release rate of therapeutically active drug for a sustained period. A Gastro retentive dosage form improves the therapy by prolonging the gastric residence time of the drugs. Prolonged gastric retention improves bioavailability, reduces drug waste and improves solubility for drugs that are less soluble in a high pH environment.In this review, we have discussed various systems associated with gastro retentive drug delivery with their effective mode of action. Also, the approaches and factors to increase the gastric retention time have also been discussed. This drug delivery system has potential to overcome the limitations of the conventional system. The present study is performed for the motivation of the graduates towards publication and research. Hence, we have encouraged the graduates to prepare an informative article on the present subject.

Keywords

Gastro-Retentive, Controlled Drug Delivery, Floating Drug Delivery, Mucoadhesion.

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References

• Jain N.K, "Advances in Controlled & Novel Drug Delivery," CBS Publishers & Distributers, New Delhi, Pg 76-95
• Timmermans J, Moes AJ. How Well Floating Dosage Form Float?. Int J Pharm 1990; 62:207‐16.2.
• Strebeul A, Siepmann J & Bodmeier R, Gastro retentive drug delivery system, Expert Opin Drug Deliv, 3 (2006) 217.
• Garg Sanjay; Sharma Shringi. Business Briefing Pharmtech, 2003, 160-166. Sangekar S. International Journal of Pharmaceutics, 1987, 35(3), 34-53.
• Neena Washington, Clive Washington and Clive G.Wilson , Physiological Pharmaceutics Barriers to drug absorption, Second Edition, 2001, 81-90.
• Patel R. Recent development in floating drug delivery system for gastric retention of drugs: an overview. 2007; http://www.swatijaininst.com/etechno/feb2007/roma.rtf 26.
• Asane GS. Mucoadhesive gastrointestinal drug delivery system: An overview. 2007; www.pharmainfo.net. 27.
• I Krogel and R Bodomeier, Floating or pulsatile drug delivery systems based on coated effervescent cores. Int J Pharm; 187; 1999; 175-184.
• P R Sheth, J L Tossounian J L, Sustained release pharmaceutical capsules. US Pat 4; 126; 672; November 21, 1978.
• S Desai and S Bolton, A controlled release drug delivery system: In vitro-in vivo evaluation. Pharm Res; 10; 1993; 1321-1325.
• P Dennis, K Timmins, S Lee, Buoyant controlled release powder formulation. US Pat 5; 169; 638; December 8, 1992.
• R M Harrigan, Drug delivery device for preventing contact of undissolved drug with the stomach lining. US Pat 4, 055; 178; October 25, 1977
• Prajapati, S.T., Patel, L.D. and Patel, D.M. Studies on formulation and in vitro evaluation of floating matrix tablets of domperidone. Indian J Pharm Sci, 2009, Vol. 71(1), pp. 19-23
• Bhavna V, Khopade AJ, Shelly WD and Jain NK: Targeted oral drug delivery. Indian Drugs 1996; 33: 365-373.
• Shah S.H., Patel J.K., Patel N.V.; stomach specific floating drug delivery syatem; IJPTR;2009, pp. 629-630.
• Rajab, M., Jouma, M., Neubert, R.H. and Dittgen, M. Optimization of a metformin effervescent floating tablet containing hydroxypropylmethylcellulose and stearic acid. Pharmazie, 2010, Vol. 65(2), pp. 97-101.
• Jagdale, S.C., Agavekar, A.J., Pandya, S.V., Kuchekar, B.S. and Chabukswar, A.R. Formulation and evaluation of gastroretentive drug delivery system of propranolol hydrochloride. AAPS PharmSciTech, 2009, Vol. 10(3), pp. 1071-1079.
• Bomma, R., Naidu, R.A.S., Yamsani, M.R. and Veerabrahma, K. Development and evaluation of gastroretentivenorfloxacin floating tablets. Acta Pharm, 2009, Vol. 59(2), pp. 211-221.
• Patel, A., Modasiya, M., Shah, D. and Patel, V. Development and in vivo floating behavior of verapamil HClintragastric floating tablets. AAPS PharmSciTech, 2009, Vol. 10(1), pp. 310-315.
• Arza, R.A.K., Gonugunta, C.S.R. and Veerareddy, P.R. Formulation and evaluation of swellable and floating gastroretentive ciprofloxacin hydrochloride tablets. AAPS PharmSciTech, 2009, Vol. 10(1), pp. 220-226.
• Garg, R. and Gupta, G.D. Preparation and evaluation of gastroretentive floating tablets of acyclovir. Curr Drug Deliv, 2009, Vol. 6(5), pp. 437-443.
• Sawicki, W., ?unio, R., Walentynowicz, O. and KubasikJuraniec, J. aInfluence of the type of cellulose on properties of multi-unit target releasing in stomach dosage form with verapamil hydrochloride. Acta Pol Pharm, 2007, Vol. 64(1), pp. 81-88.
• Goole, J., Deleuze, P., Vanderbist, F. and Amighi, K. New levodopa sustained-release floating minitablets coated with insoluble acrylic polymer. Eur J Pharm Biopharm, 2008, Vol. 68(2), pp. 310-318.
• Meka, L., Kesavan, B., Chinnala, K.M., Vobalaboina, V. andYamsani, M.R. Preparation of a matrix type multiple-unit gastro retentive floating drug delivery system for captopril based on gas formation technique: in vitro evaluation. AAPS PharmSciTech, 2008, Vol. 9(2), pp. 612-619.
• Zhai, X.-L., Ni, J. and Gu, Y.-L. Study on preparation of phenols gastric floating tablet ZhongguoZhong Yao ZaZhi, Beijing University of Traditional Chinese Medicine, Beijing 100102, China., 2008, Vol. 33(1), pp. 31-34.
• Vyas SP, Khar RK. Gastroretentive systems. In: Controlled drug Delivery. VallabhPrakashan, Delhi, India. 2006. pp. 197-217.
• Chawla G, Gupta P, Bansal AK. Gastroretentive drug delivery systems. In: Jain NK. editor. Progress in controlled and novel drug delivery systems. CBS Publishers and Distributors. New Delhi. 2004. p. 76-97.
• Vinod KR, Vasa S, Anbuazagahan S. Approaches for gastroretentive drug delivery, IJABPT, 2008; 589-601.
• Pawar V.K, Shaswat K, Garg G, Awasthi R. Gastroretentive dosage form: A review with special emphasis on floating drug delivery systems, Informa Healthcare 2011; 18(2): 97-110 9.
• Dixit N. Floating drug delivery system. Journal of Current Pharmaceutical Research, 2011 ;7(1):6-20.
• Vyas SP, Khar RK. Controlled drug delivery: concept and advances. Vallabhprakashan Delhi, 2002; 1: 123-231.
• Solanki ND, Shah S, Patel J, Upadhyay P. Formulation and evaluation of once bilayer floating tablets of antihypertensive drug involving dissolution enhancement technique. Der Pharmacia Sinica, 2013; 4(5): 54-66.
• Bhowmik D, Chiranjib B, Jayakar B. Floating drug delivery system- a review. Der Pharmacia. Lettre, 2009; 1(2): 199-218.
• Chander S, Shireesh K, Nagendra B. Preparation and evaluation of gastroretentive floating tablets of ketoconazole. IJPRD, 2010; 2(9): 175-176.
• Chandel A, Chauhan K. Gastroretentive approaches. ICPJ 2012;1:110-118.
• Khan AZ, Tripathi R, Mishra B. Floating elementary osmotic pump tablet for controlled d delivery of diethylcarbamazine citrate: a water- soluble drug. AAPS Pharm Sci Tech, 2011;12(4):1312-1323.
• SubhramananyamCVS ,Setty JT. Laboratory manual of physical pharmaceutics. Vallabhprakashan 2002;pg no 212.
• Pamu S, Banu N, Sunitha M. Formulation and evaluation of olmesartanmedoxomil floating tablets. International Journal of Pharmacy and Industrial Research, 2013;3(4):329-334.
• Vedha BN, Brahma RA, Samyuktha RB. Floating drug delivery of Nevarapine as a gastroretentive system. Journal of Yung Pharmacist, 2010;2(4)350-355.
• Boldhane SP and Kuchekar BS. Development and optimization of metoprolol succinate gastroretentive drug delivery system. Acta Pharm, 2010;60:415-425.

• Self Microemulsifying Drug Delivery System (SMEDDS): A Novel Approach to Improve the Therapeutic Efficacy of Orally Administered Drug

Abstract Views :501  |  PDF Views:0

Authors

Kritika Kanoujia ¹, Chandraprabha Dewangan ¹, AyushI Masih ¹, Dipti Sinha ¹, Divya Oraon ¹, Manisha Jaiswal ¹, Monika Sahu ¹, Ranjeeta Kumari ¹, Sapna Pradhan ¹, Ravi Suman ¹, Rajkishan Dewangan ¹, Roman Banjare ¹, Pradeep Paikra ¹, Mukesh Rawtiya ¹, Mukta Agrawal ¹, Ajazuddin ¹, D. K. Tripathi ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, IN

Source

Research Journal of Pharmaceutical Dosage Form and Technology, Vol 10, No 2 (2018), Pagination: 95-102

Abstract

The oral route is most preferred one as there is ease of administration and it is a painless approach. This favored route is restricted to those drug molecules that are absorbent over gastric mucosa. One of the promising techniques is SMEDDS. Self-micro emulsifying drug delivery system has gained more attention due to enhanced oral bioavailability enabling a reduction in dose, more consistent temporal profiles of drug absorption, selective targeting of drug towards specific absorption window in GIT, and protection of drugs from the unreceptive environment in the gut. SMEDDS provide the dissolved drugs form,and also its small size of droplets imparts substantial interfacial area for the absorption of drugs. It can simply get penetrated into the GIT which is the major advantages over another emulsion. The present study is performed for the motivation of the graduates towards publication and research. Hence, we have encouraged the graduates to prepare an informative article on the present subject.

Keywords

SMEDDS, Oral Drug Delivery, GIT, Solubility, Bioavailability.

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References

• Shraddha D. Pawar NAG, Bhushan R.Rane, Sunil P. Pawar. Selfmicro emulsifying drug delivery system (smedds): apromising drug delivery system for enhancement of bioavailability. Indian Journal of Drugs. 2016; 4(3): 90-108.
• Sheo Datta Maurya RKKA, G. Rajpal, Ram C. Dhakar. Self-Micro Emulsifying Drug Delivery Systems (Smedds): A Review On Physico-Chemical And Biopharmaceutical Aspects. Journal of Drug Delivery and Therapeutics. 2017; 7(3): 55-65.
• Pouton CW. Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2000; 11 Suppl 2:S 93-8.
• Deepa P, Krutika KS. Self Micro-Emulsifying Drug Delivery System: Formulation Development and Biopharmaceutical Evaluation of Lipophilic Drugs. Current drug delivery. 2009; 6(4): 419-24.
• Craig DQM, Barker SA, Banning D, Booth SW. An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy. International journal of pharmaceutics. 1995; 114(1): 103-10.
• Gershanik T, Benita S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik eV. 2000; 50(1): 179-88.
• Jang Y-J, Cho KH. Preparation and characterization of solidified SMEDDS containing flurbiprofen by spray drying method. Asian Journal of Pharmaceutical Sciences. 2016; 11(1): 108-9.
• Kamel R, Basha M. Preparation and in vitro evaluation of rutin nanostructured liquisolid delivery system. Bulletin of Faculty of Pharmacy, Cairo University. 2013;51(2):2 61-72.
• Dokania S, Joshi AK. Self-microemulsifying drug delivery system (SMEDDS) – challenges and road ahead. Drug delivery. 2015; 22(6): 675-90.
• Akula S, Gurram AK, Devireddy SR. Self-Microemulsifying Drug Delivery Systems: An Attractive Strategy for Enhanced Therapeutic Profile. International Scholarly Research Notices. 2014; 2014: 11.
• Chen Y, Li G, Wu X, Chen Z, Hang J, Qin B, et al. SelfMicroemulsifying Drug Delivery System (SMEDDS) of Vinpocetine: Formulation Development and in Vivo Assessment. Biological and Pharmaceutical Bulletin. 2008; 31(1): 118-25.
• Ansari KA, Pagar KP, Anwar S, Vavia PR. Design and optimization of self-microemulsifying drug delivery system (SMEDDS) of felodipine for chronotherapeutic application. Brazilian Journal of Pharmaceutical Sciences. 2014; 50: 203-12.
• Khan BA BS, Khan H, Mahmood T, Rasul A. Basics of self micro emulsifying drug delivery system. Journal of pharmacy and alternative medicine. 2012; 1.
• Swati Gokul Talele VRG. Novel approaches for solidification of SMEDDS. J Pharm BioSci. 2015;5:90-101.
• Lade S TU, Burle S, Kosalge S. Self emulsifying drug delivery system- A novel approach to improve oral bioavailability. Eur Jour Pharm Med Res. 2016; 3(1): 164-73.
• Li F, Hu R, Wang B, Gui Y, Cheng G, Gao S, et al. Selfmicroemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake. Acta Pharmaceutica Sinica B. 2017; 7(3): 353-60.
• Pandey V, Kohli S. SMEDDS of pioglitazone: Formulation, invitro evaluation and stability studies. Future Journal of Pharmaceutical Sciences. 2017; 3(1): 53-9.
• Suparna S. Bakhle JGA. Development and Evaluation of Liquid and Solid Self-microemulsifying Drug Delivery System of Lovastatin. Asian Journal of Pharmaceutics. 2016; 10(1): 22.
• Wu H, Long X, Yuan F, Chen L, Pan S, Liu Y, et al. Combined use of phospholipid complexes and self-emulsifying microemulsions for improving the oral absorption of a BCS class IV compound, baicalin. Acta Pharmaceutica Sinica B. 2014; 4(3): 217-26.
• Sapra K SA, Singh SK, Kakkar S. Self emulsifying drug delivery system: A tool in solubility enhancement of poorly soluble drugs. Indo global journal of pharmaceutical science. 2012; 2(30): 313-32.
• Pattewar S KS, Pande V, Sharma S. . Self microemulsifying drug delivery system: A lipid based drug delivery system. Int J Pharm Sci Res. 2016; 7(2): 443-52.
• Durgacharan Arun Bhagwat JIDS. Formulation and evaluation of solid self micro emulsifying drug delivery system using aerosil 200 as solid carrier. International Current Pharmaceutical Journal 2012; 1(12): 414-9.
• Rawat S DD, Parve BS, Shinde PR. Self emulsifying drug delivery system: A method for bioavailability enhancement. International journal of pharmaceutical, chemical and biological sciences. 2014; 4(3): 479-94.
• Qureshi MJ, Mallikarjun C, Kian WG. Enhancement of solubility and therapeutic potential of poorly soluble lovastatin by SMEDDS formulation adsorbed on directly compressed spray dried magnesium aluminometasilicate liquid loadable tablets: A study in diet induced hyperlipidemic rabbits. Asian Journal of Pharmaceutical Sciences. 2015; 10(1): 40-56.
• Prajapati ST, Joshi HA, Patel CN. Preparation and Characterization of Self-Microemulsifying Drug Delivery System of Olmesartan Medoxomil for Bioavailability Improvement. Journal of Pharmaceutics. 2013;2013:9.
• Abdalla A KS, Mader K. A new selfemulsifying drug delivery system (SEDDS) for poorly soluble drugs: Characterization, dissolution, in vitro digestion and incorporation into solid pellets. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2008; 35: 457-64.
• Tak JW, Poudel BK, Shiva P, Go TK, Woo Kb, Kim DS, et al. Preparation and optimization of fenofibrate loaded selfmicroemulsifying drug delivery system (SMEDDS) by application of box-behnken design. Asian Journal of Pharmaceutical Sciences. 2015.
• Prachi S PS, Upendra SK, Shipra S, Ali A. A review on self microemulsifying drug delivery system: An approach to enhance the oral bioavailability of poorly water soluble drugs. Int Res Jour Pharm. 2012; 3(9): 1-6.
• Bipin kumar DJ DPM. Self microemulsifying drug delivery system: A Review. World journal of pharmacy and pharmaceutical sciences. 2016;5(4):2215-32.
• Maulik J. Patel SSP, Natvarlal M. Patel, Madhabhai M. Patel. A Self-Microemulsifying Drug Delivery System (SMEDDS). International Journal of Pharmaceutical Sciences Review and Research 2010;4(3):29-35.

• Understanding the Concept of Mucoadhesive Drug Delivery System: A Novel Approach over Conventional Dosage Forms

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Authors

Umesh Kumar ¹, Khuman Lal ¹, Navneet Patel ¹, Lekhraj ¹, Jai Prakash ¹, Omkar ¹, Rakesh Gurjar ¹, Achyutanand Gupta ¹, Chandra Prakash ¹, Mukta Agrawal ¹, Ajazuddin ¹, D. K. Tripathi ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, IN

Source

Research Journal of Pharmaceutical Dosage Form and Technology, Vol 10, No 2 (2018), Pagination: 103-108

Abstract

Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for the improved therapeutic outcome. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first-pass metabolism. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. The present study is performed for the motivation of the graduates towards publication and research. Hence, we have encouraged the graduates to prepare an informative article on the present subject.

Keywords

Mucoadhesion, Mucoadhesive System, Bioadhesion, Transmucosal, Transdermal, Bioavailability.

Full Text

     

References

• Netsomboon K, Bernkop-Schnurch A. Mucoadhesive vs. mucopenetrating particulate drug delivery. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik eV. 2016; 98:76-89.
• Silva BM, Borges AF, Silva C, Coelho JF, Simoes S. Mucoadhesive oral films: The potential for unmet needs. International journal of pharmaceutics. 2015; 494(1): 537-51.
• Montenegro-Nicolini M, Morales JO. Overview and Future Potential of Buccal Mucoadhesive Films as Drug Delivery Systems for Biologics. AAPS PharmSciTech. 2017; 1 8(1): 3-14.
• Shinkar DM, Dhake AS, Setty CM. Drug delivery from the oral cavity: a focus on mucoadhesive buccal drug delivery systems. PDA journal of pharmaceutical science and technology. 2012; 66(5): 466-500.
• Laffleur F. Mucoadhesive polymers for buccal drug delivery. Drug development and industrial pharmacy. 2014; 40(5): 591-8.
• Duggan S, Cummins W, O OD, Hughes H, Owens E. Thiolated polymers as mucoadhesive drug delivery systems. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2017; 100: 64-78.
• Cook MT, Khutoryanskiy VV. Mucoadhesion and mucosamimetic materials--A mini-review. International journal of pharmaceutics. 2015; 495(2): 991-8.
• Gilhotra RM, Ikram M, Srivastava S, Gilhotra N. A clinical perspective on mucoadhesive buccal drug delivery systems. Journal of biomedical research. 2014; 28(2): 81-97.
• Bruschi ML, de Francisco LM, A SdTL, Borghi FB. An overview of recent patents on composition of mucoadhesive drug delivery systems. Recent Pat Drug Deliv Formul. 2015; 9(1): 79-87.
• Bagan J, Paderni C, Termine N, Campisi G, Lo Russo L, Compilato D, et al. Mucoadhesive polymers for oral transmucosal drug delivery: a review. Current pharmaceutical design. 2012; 18(34): 5497-514.
• Agarwal S, Aggarwal S. Mucoadhesive polymeric platform for drug delivery; a comprehensive review. Current drug delivery. 2015; 12(2): 139-56.
• Priya Mahajan AK, Geeta Aggarwal, S.L. Harikumar. Mucoadhesive Drug Delivery System: A Review. Int J Drug Dev & Res. 2013 ;5(1):11-20.
• Remunan-Lopez C, Portero A, Vila-Jato JL, Alonso MJ. Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery. Journal of controlled release : official journal of the Controlled Release Society. 1998; 55(23):143-52.
• Shojaei AH. Buccal mucosa as a route for systemic drug delivery: a review. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 1998; 1(1): 15-30.
• Caramella CM, Rossi S, Ferrari F, Bonferoni MC, Sandri G. Mucoadhesive and thermogelling systems for vaginal drug delivery. Advanced drug delivery reviews. 2015; 92: 39-52.
• Hornof M, Weyenberg W, Ludwig A, Bernkop-Schnurch A. Mucoadhesive ocular insert based on thiolated poly(acrylic acid): development and in vivo evaluation in humans. Journal of controlled release : official journal of the Controlled Release Society. 2003; 89(3): 419-28.
• Sultana Y, Aqil M, Ali A. Ocular inserts for controlled delivery of pefloxacin mesylate: preparation and evaluation. Acta pharmaceutica (Zagreb, Croatia). 2005; 55(3): 305-14.
• Singh RM, Kumar A, Pathak K. Mucoadhesive in situ nasal gelling drug delivery systems for modulated drug delivery. Expert opinion on drug delivery. 2013; 10(1): 115-30.
• Khan Shahid VM, Aggarwal Geeta and Kumar S. L. Hari. Mucoadhesive drug delivery system: A review. World Journal of Pharmacy and Pharmaceutical Sciences. 2016; 5(5): 392-405.
• Harvinder Kaur Saini UN. Pioneering and Encouraging Approach Mucoadhesive Drug Delivery System. International Journal of Pharmaceutical and Medicinal Research. 2017; 5(3): 455-63.
• Rahamatullah Shaikh TRRS, Martin James Garland, A David Woolfson, and Ryan F. Donnelly. Mucoadhesive drug delivery systems. J Pharm Bioallied Sci 2010; 3(1): 89-100.
• B. Saraswathi Abamsu. Polymers in mucoadhesive drug delivery system-latest updates International Journal of Pharmacy and Pharmaceutical Sciences. 2013; 5(3):4 23-30.
• Vinod KR RRT, Sandhya S, David Banji, Venkatram Reddy B. Critical Review on Mucoadhesive Drug Delivery Systems. Hygeia JD Med. 2012; 4(1):7-28.
• Pranshu Tangri NVSM. Oral Mucoadhesive Drug Delivery Systems: A Review. International Journal of Biopharmaceutics. 2011; 2(1): 36-46.
• Folch J, Petrov D, Ettcheto M, Abad S, #xe1, nchez-L, et al. Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment. Neural Plasticity. 2016; 2016: 15.